Masao Mitsuyama Selected Research

Listeria monocytogenes hlyA protein (listeriolysin O)

1/2022	Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.
1/2015	Inactivation of the MAPK signaling pathway by Listeria monocytogenes infection promotes trophoblast giant cell death.
6/2008	Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin O, after evasion from phagosome into the cytoplasm.
8/2007	Cytolysin-dependent escape of the bacterium from the phagosome is required but not sufficient for induction of the Th1 immune response against Listeria monocytogenes infection: distinct role of Listeriolysin O determined by cytolysin gene replacement.
7/2005	Listeriolysin O-induced membrane permeation mediates persistent interleukin-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro.

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Masao Mitsuyama Research Topics

Disease

19	Infections 01/2019 - 01/2003
4	Necrosis 05/2011 - 01/2003
3	Listeriosis (Listeria Infection) 01/2022 - 07/2005
3	Melanoma (Melanoma, Malignant) 06/2014 - 07/2010
2	Pneumococcal Pneumonia 01/2019 - 06/2014
2	Pneumococcal Infections 06/2014 - 11/2011
2	Tuberculosis (Tuberculoses) 05/2011 - 01/2003
2	Wounds and Injuries (Trauma) 07/2007 - 12/2005
2	Catheter-Related Infections 07/2007 - 12/2005
2	Granuloma 01/2007 - 01/2003
1	Communicable Diseases (Infectious Diseases) 01/2022
1	Pancreatitis 01/2013
1	Cryopyrin-Associated Periodic Syndromes 08/2012
1	Mitochondrial Diseases (Mitochondrial Disease) 09/2007
1	Hypersensitivity (Allergy) 04/2003

Drug/Important Bio-Agent (IBA)

6	InflammasomesIBA 01/2022 - 07/2010
6	Interleukin-18 (Interleukin 18)IBA 12/2014 - 01/2003
5	Listeria monocytogenes hlyA protein (listeriolysin O)IBA 01/2022 - 07/2005
5	CytokinesIBA 09/2009 - 01/2003
4	Proteins (Proteins, Gene)FDA Link 01/2015 - 01/2007
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2010 - 01/2003
2	Interleukin-6 (Interleukin 6)IBA 05/2011 - 07/2005
2	Interleukin-1alpha (Interleukin 1 alpha)IBA 05/2010 - 04/2008
2	Interleukin-12 (IL 12)IBA 06/2008 - 01/2003
2	PerforinIBA 06/2008 - 08/2007
1	Amino Acids FDA Link 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	Interleukin-10 (Interleukin 10)IBA 12/2014
1	Interferon Type IIBA 06/2014
1	Chelating AgentsIBA 02/2014
1	AutoantibodiesIBA 01/2013
1	Protein Disulfide-IsomerasesIBA 01/2013
1	Pharmaceutical PreparationsIBA 08/2012
1	Interferon-betaIBA 07/2012
1	NucleotidesIBA 11/2011
1	Mycobacterium tuberculosis PPE37 proteinIBA 05/2011
1	LigandsIBA 12/2010
1	AntigensIBA 12/2010
1	DNA (Deoxyribonucleic Acid)IBA 07/2010
1	alpha-galactosylceramideIBA 06/2010
1	CalpainIBA 05/2010
1	Peptide Hydrolases (Proteases)FDA Link 05/2010
1	CalciumIBA 05/2010
1	Interleukin-12 Subunit p40IBA 04/2008
1	Streptococcus pneumoniae plY proteinIBA 04/2008
1	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2007
1	Adenosine Triphosphate (ATP)IBA 09/2007
1	Virulence Factors (Pathogenicity Factors)IBA 09/2007
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 07/2007
1	Caspase 9IBA 06/2007
1	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 06/2007
1	CaspasesIBA 06/2007
1	ChemokinesIBA 01/2007
1	Vancomycin FDA LinkGeneric 08/2006
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 04/2003
1	Messenger RNA (mRNA)IBA 01/2003
1	TrehaloseIBA 01/2003
1	VaccinesIBA 01/2003

Therapy/Procedure

2	Catheters 07/2007 - 12/2005